NIH R01 · 2024
Interactions of Leptin and the Melanocortin System
PROJECT SUMMARY The increasing rates of obesity and diabetes highlight the need to understand the brain circuits and cellular mechanisms regulating energy balance and glucose homeostasis. Prominent among these is the central leptin- melanocortin system, which includes the pro-opiomelanocortin (POMC) neurons, subsets of which express leptin receptors (LEPRs). While enormous strides have been made to understand the role of hypothalamic POMC neurons that produce α-MSH in metabolism, relatively little is known about how the three isoforms of - MSH produced in hypothalamus and pituitary gland POMC-expressing cells respond to metabolic challenges. The current application extends our previous…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.