Elmariah Lab

Research focus

NIH R01 · 2024

Multi-omic markers of cardiac function and structure within the pressure overloaded heart

PROJECT SUMMARY/ABSTRACT This proposed study is motivated by the public health importance of aortic stenosis (AS), a common form of valvular heart disease that is associated with substantial morbidity and mortality. Once symptomatic, survival is a dismal 50% at 1-year if left untreated. Clinical symptoms develop once cardiac compensatory mechanisms fail, indicating the need for aortic valve replacement (AVR), but because AS primarily affects the elderly, symptoms are often incorrectly attributed to comorbid conditions, advanced age, or both—resulting in delayed treatment. While most patients that eventually undergo AVR experience improvements in symptoms and survival, nearly half of…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.