NIH R01 · 2025
WNK Kinase Regulation of Thiazide-sensitive NaCl Transport
Project Summary Salt transport by the kidney is dysregulated in many diseases, including heart failure and hypertension. This project is designed understand how sodium chloride reabsorption along the distal nephron in the kidney is regulated by diet and disease. The work will focus on the distal convoluted tubule and the thiazide-sensitive NaCl cotransporter, which play key roles in regulating arterial pressure, systemic potassium balance, and the development of resistance to diuretic drugs. The thiazide-sensitive NaCl cotransporter is activated by low NaCl intake or low potassium intake through WNK kinases, which eventually affect its phosphorylation status. Low potassium intake reduces…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.