NIH R01 · 2025
PROJECT SUMMARY This proposal aims to evaluate and optimize Photodynamic Therapy (PDT) as an adjuvant treatment for contaminated high-energy open fractures to reduce bacterial bioburden and, thus, reduce rate of infection. Infection following fracture treatment is one of the most challenging complications facing musculoskeletal trauma patients. Infection can be catastrophic, leading to prolonged morbidity, loss of function, and potential loss of limb. Several factors make high-energy open trauma particularly susceptible to infection: the presence of traumatized tissues, contamination of the fracture, poor soft tissue coverage, poor nutritional state due to polytrauma, prolonged…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.