NIH R01 · 2025
Using Electrocardiogram Genetics to Inform Arrhythmia Risk
Project summary Nearly one in three people will have an arrythmia during their lifetime and up to 10% may die of sudden cardiac death. Arrhythmias and sudden cardiac death are heritable and often caused by problems of cardiac conduction or repolarization. Nevertheless, the genetic causes are not well-defined. Moreover, interpretation of genetic variation is limited by the frequent discovery of variants of uncertain clinical significance. Our preliminary data suggest that using high-depth genomic sequencing data from large-scale biobanks with routinely measured electrocardiogram intervals – indicators of arrhythmia and sudden cardiac death risk – has the potential to address these…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.