NIH R01 · 2025
Effects of host endocannabinoid signaling on Enterobacteriaceae infection
PROJECT SUMMARY The Escherichia coli species encompass innocuous commensals, resident pathobionts, and invading pathogens. In the gut, the proliferation of E. coli and other Enterobacteriaceae, and their potential to induce or contribute to disease, is dependent on the reduction or complete loss of colonization resistance. Host, microbial, and environmental factors can all contribute to lowering colonization resistance to facilitate Enterobacteriaceae expansion, which represents a common hallmark of microbiome dysfunction in many chronic diseases including Crohn’s disease. Supported by our extensive preliminary data, this proposal will define a novel mechanism by which a host signaling…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.