NIH R01 · 2024
Adipocyte cytokine signaling as a coordinator of adipose tissue function
Adipose tissue inflammation directly contributes to the overall inflammatory state in obesity, with immune cells being intimately involved regulating adipocyte function and vice versa. The cytokine, oncostatin M (OSM), is produced by adipose tissue macrophages. Our published data suggests that lack of OSM signaling on adipocytes via its receptor (OSMR) leads to adipose tissue inflammation and insulin resistance. Our preliminary data indicate that OSM signaling on adipocytes is required for proper adipose tissue function. The mechanisms adipocytes utilize to regulate adipose tissue inflammation in both health and disease remain unclear. We aim to address this knowledge gap by proposing a new…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.