NIH R01 · 2025
Energy Metabolism in Osteoblasts and Bone Health
Energy Metabolism in Osteoblasts and Bone Health Energy metabolism is an important regulator of cell fate and tissue homeostasis while its dysregulation is a hallmark of aging in various tissues, including bone. Data on energy metabolism in osteoblasts (OB) are contra- dictory, claiming OB reliance either on aerobic glycolysis or mitochondrial oxidative phosphorylation (OxPhos). With regards to bioenergetic substrates, glutamine and fatty acids were recently shown to be as important for OBs as glucose; and they are metabolized mostly in mitochondria. Our new exciting data suggest an explanation to the above controversies and can reconcile the opposing views on OB metabolism. First, we…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.