NIH R01 · 2024
TonEBP/Nfat5, vesicular trafficking and intervertebral disc maintenance
Abstract/Summary The discovery of new disease-modifying treatments for low back pain and spine degeneration requires a more complete understanding of the mechanisms controlling intervertebral disc (IVDs) formation and maintenance. Our objective in this proposal is to use knowledge from a series of conditional mouse models, where TonEBP is ablated in specific compartments of the IVD, (i) to characterize a newly identified function of TonEBP as a component of the machinery required for vesicular protein transport and secretion and ii) to improve our understanding of the nature of the interactions between IVD compartments during formation and maintenance of the spine. Our central hypothesis is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.