NIH R01 · 2025
Mechanisms underlying Tip60 HAT action in neuroprotection of cognitive function
ABSTRACT Alzheimer’s disease (AD) is a debilitating progressive neurodegenerative disorder (ND) hallmarked by initial mild cognitive impairment (MCI) followed by dementia. The severity of AD progression is dependent upon the complex interplay between genetics, age, and environmental factors orchestrated in large part, by epigenetic histone acetylation (HA) mediated gene regulatory mechanisms. HA homoeostasis in the brain is maintained by antagonizing histone acetyltransferase (HAT) and histone deacetyltransferase (HDAC) enzymes that generate and erase cognition-linked histone acetylation marks, respectively. Reduced HA levels in the brain cause chromatin packaging alterations in neurons,…
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