Eldaief Lab

Massachusetts General Hospital

Boston · United States

NIH-funded
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NIH R01 · 2024

Probing the Functional and Behavioral Impact of Precision Circuit Modulation in Neuropsychiatric Disorders

Project Summary/Abstract Network models are increasingly invoked to characterize the neurobiological underpinnings of mental illnesses. Dysfunction within specific circuits promotes the formation of specific symptoms. This suggests an opportunity to treat specific symptoms by modulating specific circuits. Repetitive transcranial magnetic stimulation (rTMS) is capable of circuit-specific neuromodulation. It is also an established treatment for Major Depressive Disorder (MDD). Clinical experience suggests that rTMS treats different symptom constructs by stimulating different circuits. However, there remains a critical lack of mechanistic evidence to support putative network mechanisms of…

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