NIH R01 · 2024
Mechanisms Underlying Excitability Regulation of Motoneuron Types in ALS
Project Summary/Abstract Multifarious pathologies of amyotrophic lateral sclerosis (ALS) have been studied, yet effective treatments remain elusive. Abnormalities in motoneuron (MN) excitability remain the most tightly linked to disease path- ogenesis. The central hypothesis of this proposal is that these abnormalities are not an epiphenomenon of ALS, but rather an early pathophysiologic event that initiates the events leading to MN death. Paradoxically, both MN HYPER- and HYPO-excitability changes have been seen at various disease stages, in multiple lines of ALS mice. The lack of clarity on what roles hyper- and hypo-excitability changes play (i.e., neuropro- tective or detrimental), and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.