NIH R01 · 2025
SUMMARY/ABSTRACT Cancer associated fibroblasts and pancreatic stellate cells (PSC/CAF) and abnormal tumor blood vessels are two major factors that contribute to treatment failure. PSC/CAF contribute to the collagen-rich extracellular matrix (ECM) which impairs drug delivery, promotes cancer cell survival and contributes to an immunosuppressive environment. CAF have been shown to have a similar role in supporting metastatic sites of disease in PDAC. Currently, no agent is available that can simultaneously selectively reduce activated PSC/CAF and normalize angiogenesis. Both activated PSC/CAF and angiogenic endothelial cells selectively express high levels of integrin v3. There is no…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.