NIH R01 · 2024
SUMMARY/ABSTRACT The overarching goal of this proposal is to identify and characterize mechanistic pathways in astrocytes responsible for changes in drug-evoked structural and synaptic plasticity that underlie the maladaptive behavior in opioid drug abuse. Astrocytes are a logical focus for these studies, as they are intimately involved in diverse neuronal function, including modulation of synaptic function and plasticity, regulating concentrations of the excitatory neurotransmitter glutamate, and yet secrete and response to neuroinflammatory cytokines, chemokines, and growth factors. These processes are themselves regulated by autophagy: the process by which cells both engage in orderly…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.