NIH R01 · 2025
Epigenetic Control of Nephron Progenitor Cell Lifespan
SUMMARY In mice and humans, nephrogenesis ceases perinatally and so is the opportunity to generate new nephrons following congenital or acquired loss of renal mass. A significant barrier to progress in the renal regeneration field is insufficient knowledge surrounding the mechanisms driving cessation of nephrogenesis. Recent genetic and epigenetic evidence support the notion that the lifespan of nephron progenitor cells (NPCs) is not fixed. The mechanisms whereby perinatal NPCs cease to self-renew and exhibit distinct metabolic fuel requirement and enhanced responsiveness to differentiation factors are under intense investigations. Initial comparative analysis of the chromatin landscape and…
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