Bortfeld Lab

H. Lee Moffitt Cancer Ctr & Res Inst

Tampa · United States

NIH-funded
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NIH R01 · 2024

An Ionizing Radiation Acoustics Imaging (iRAI) Approach for guided Flash Radiotherapy

SUMMARY An emerging radiotherapy (RT) modality that utilizes ultra-high dose rate, known as FLASH-RT, has demonstrated unprecedented ability for improving RT therapeutic ratio in preclinical studies and early clinical cases. Because of lack of appropriate image-guidance technologies, these studies have been limited to superficial irradiations and simplistic cases where monitoring of delivered dose is permissible using existing methods. This severely handicaps the prospects of FLASH-RT and largely limits its promising impact for deep seated tumors, which constitute most of RT cancer cases. It is widely recognized that currently used dosimetry technologies fall short of providing the…

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