NIH R01 · 2025
Imaging and multi-omics analyses to identify molecular subtypes of distinct emphysema patterns
PROJECT SUMMARY/ABSTRACT Chronic obstructive pulmonary disease (COPD) is a progressive, debilitating disease in critical need of disease- modifying treatments. Emphysema, progressive lung destruction commonly encountered in subjects with COPD, portends a poor prognosis. This project will leverage two large well-phenotyped, NHLBI-funded studies (the COPDGene and Lung Tissue Research Consortium (LTRC)) and the team’s extensive expertise in modern imaging techniques, multi-omics data analysis, machine learning approaches, and in vitro functional validation. The overall objective of this application is to identify novel multi-omics biomarkers and molecular subtypes of centrilobular, panlobular,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.