NIH R01 · 2025
Non-Invasive MRI Markers to Elicit the Role of Vascular Disease in CADASIL Compared to Normal Aging
Project Summary/Abstract: The project addresses vascular contributions to cognitive impairment and dementia (VCID) using a design that enrolls persons with the autosomal dominant gene for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). Exploration of VCID by focusing on the rare heritable monogenic disorder, CADASIL, will advance knowledge of the full spectrum of this vascular dementia from asymptomatic gene carriers through dementia and will facilitate studies evaluating vascular contributions in different neurodegenerative processes including Alzheimer’s disease (AD) and related dementias (ADRD). CADASIL is caused by a mutation in the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.