NIH R01 · 2024
Monodisperse Microbubbles for Noninvasive Pressure Estimation
Project Summary The current clinical standard for quantifying fluid pressures relies on the invasive placement of pressure catheters or needles. These measures are costly and not without risk, thereby reducing how often data is collected. Ultrasound contrast agents (UCA) are gas-filled microbubbles that, when insontated at a fundamental frequency (f0), act as nonlinear oscillators, generating signal components ranging from the subharmonic (f0/2) through higher harmonics. The subharmonic amplitude of UCA exhibits a linear relationship with hydrostatic pressure, leading to the technique of subharmonic-aided pressure estimation (SHAPE). SHAPE optimizations to date have relied primarily on…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.