NIH R01 · 2024
Immune Mechanisms Regulating Allergy
PROJECT SUMMARY The aim of this proposal is to discover the cellular and molecular pathways regulated by IL-13 that promote B cell production of high affinity IgE to allergens. Despite the importance of IgE in allergic responses, the signals that instruct B cells to produce high affinity, sialylated and long-lived IgE are not well understood. Recently we discovered in mice and humans a rare subset of T follicular helper (Tfh) cells, known as Tfh13 cells, that produce IL-13 and are required for high affinity IgE production. Ablation of of IL-13 specifically from Tfh13 cells causes a loss of high affinity IgE and prevents anaphylaxis. Additionally, we have demonstrated that the receptor for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.