NIH R01 · 2024
Behavioral pattern separation: orchestration by lateral entorhinal cortex-hippocampal circuitry
PROJECT SUMMARY/ABSTRACT The discrimination of highly similar episodes is termed behavioral pattern separation. This episodic memory process is altered by stress and decreased in humans with and rodent models for a range of brain disorders, including post-traumatic stress disorder (PTSD). Behavioral pattern separation is also susceptible to “load”; it is harder to discriminate episodes that are very similar (high load) vs. different (low load). Defining the underlying circuitry in memory stages and load-sensitivity is a key step to a future where poor behavioral pattern separation might be treated via circuit-based manipulations. The focus of this application is the role of the lateral…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.