Bueno Fernandez Lab

Research focus

NIH R01 · 2024

Role of plasma cells in chronic rejection after lung transplantation

SUMMARY Lung transplantation (LTx) is the only life-saving intervention for many patients with end-stage lung disease. The long-term survival after LTx, however, is severely limited primarily due to chronic rejection of the allograft (chronic lung allograft dysfunction - CLAD). Bronchiolitis obliterans syndrome (BOS) is the most frequent phenotype of CLAD. It is characterized by partial to complete obliteration and luminal occlusion of distal airways and includes features of subepithelial cellular inflammation, peribronchial and interstitial fibrosis, and selective loss of club cells within the airway epithelium. The pathogenesis of CLAD remains poorly understood, largely due to a lack of…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.