NIH R01 · 2025
Project Summary/Abstract Human immunodeficiency virus infects cells of the immune system and, if left untreated leads to the development of acquired immunodeficiency syndrome and death. With the advent of antiretrovirals, HIV infection has turned into a chronic infection. However, tools and therapeutics to dissect and deplete SIV/HIV latent reservoirs during combination antiretroviral therapy (ART) to interrogate their importance in defining reservoir dynamics are limited and are a focus of this application. Programmed cell death protein 1 (PD-1) is an immune checkpoint protein expressed on latently infected CD4 T cells and in particular T follicular helper (TFH) cells. TFH cells reside in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.