NIH R01 · 2025
Discriminating the contributions of CCR4 and CCR7 to thymic central tolerance
ABSTRACT As T cells develop in the thymus, VDJ recombination generates diverse T cell receptors (TCRs) needed to recognize the myriad pathogens encountered throughout life, but also yields TCRs that recognize self-antigens and could thus induce autoimmunity. Central tolerance limits autoimmunity by enforcing negative selection of thymocytes expressing TCRs with high affinity for self-antigens or diverting them to the regulatory T cell (Treg) lineage. To undergo self-tolerance, thymocytes must enter the thymic medulla, where they encounter dendritic cells (DCs) and medullary thymic epithelial cells (mTECs), key antigen presenting cell types that collectively display most self-antigens.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.