NIH R01 · 2025
Effects of alcohol on sleep/activity rhythms: Focus on Hypocretin/Orexin
PROJECT SUMMARY/ABSTRACT Clinical studies have demonstrated that drinking typically begins in adolescence and may lead to alcohol use disorders (AUD). Both younger and older adults with heavy drinking/AUDs are twice as likely to have insomnia that can last for several years. Yet the complex interactions between sleep, drinking, and maintenance of sobriety remain poorly understood despite their profound clinical implications. We postulate that cycles of binge drinking and withdrawal can lead to hyper-arousal states that disrupt sleep and may further drive drinking. One barrier to progress in testing this hypothesis has been the lack of translatable animal models that would allow the control…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.