NIH R01 · 2024
ZFP36, an RNA Binding Protein that Regulates DNA Repair and Cell Proliferation in PAH
SUMMARY Pulmonary Arterial Hypertension (PAH) is a pulmonary vascular disease characterized by increased pulmonary arterial pressure. PAH patients are young, have poor life quality, and have a short life expectancy. This daunting fact underscores our need for innovative approaches in PAH. PAH arises from a pro-proliferative and anti-apoptotic phenotype of pulmonary arterial smooth muscle cells (PASMC), endothelial cells (PAEC), and fibroblast. Recent advances linked this phenotype to a genome-wide deregulation of gene expression. Therefore, it is imperative to decode the cause of this deregulation to find new therapies. Regulation of gene expression is governed, in large part, by one main…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.