NIH R01 · 2024
Retinal Neuronal Signaling in Early Diabetes
Project Summary Diabetic retinopathy is a disease of both neurons and vasculature in the retina. Visual function deficits and neuronal retinal dysfunction from electroretinograms, are some of the earliest identifiable diabetic retinal problems, especially in the dim light activated rod pathways. Dysfunction of the inner retina - bipolar cells that receive rod input, ganglion cells that receive bipolar cell input and amacrine cells that modulate this pathway- is tied to the development of serious diabetic retinal problems. We have shown deficits in light-evoked responses of rod pathway inner retinal neurons that are not due to cell death, but the neuronal mechanisms that cause these deficits…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.