NIH R01 · 2024
Identifying the pro-metastatic mechanisms of neutrophil extracellular traps
PROJECT SUMMARY Every year, ~40,000 women in the US who had been successfully treated for primary breast cancer nonetheless have metastatic recurrence. Metastasis requires four key steps: 1) tumor cells leave the tumor; 2) tumor cells enter a new tissue; 3) disseminated tumor cells (DTCs) re-initiate proliferation; and 4) an inflammatory microenvironment is established to support the growing metastasis. Steps 1-2 often happen before the cancer is diagnosed and are rarely amenable to intervention, but we may be able to target steps 3-4 to reduce the occurrence of metastasis. To accomplish this long-term goal, we must determine a) how the quiescent DTCs re-initiate proliferation and b) how…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.