NIH R01 · 2025
PROJECT SUMMARY/ABSTRACT The median survival in adults with repaired coarctation of aorta (COA) is ~55 years, and more that 50% of deaths are due to end-stage heart failure and sudden cardiac death from left ventricular (LV) systolic/diastolic dysfunction. LV dysfunction results from chronic pressure overload from hypertension, which in turn leads to LV remodeling (increased fibrosis and stiffness, and impaired relaxation). LV dysfunction has been observed in COA patients with borderline hypertension or stage 1 hypertension (B/S1) (blood pressure 120-139/80-89 mmHg), even though the severity of hypertension in these patients is considered significant enough to warrant antihypertensive…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.