NIH R01 · 2025
Molecular mechanisms of CD8 T cell fate decision instructed by cytokine signaling
Abstract In response to viral infection or vaccination, antigen(Ag)-specific CD8 T cells that are present at low frequencies undergo rapid clonal expansion. While the majority of activated CD8 T cells become terminally differentiated effector T (T ECF) cells following expansion and die after Ag clearance, a small fraction of them persists as memory cells (Tr,1er,:) that contribute to long-term protection. However, it remains incompletely understood how cell-extrinsic stimuli through TCR and cytokine receptors establish the gene regulatory networks that determine the fates of activated CD8 T cells. The overall goal of this grant is to dissect the molecular and cellular mechanisms by which…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.