NIH R01 · 2024
Muller cell activation and remodeling in AMD.
Age-related macular degeneration (AMD) is a complex, multifactorial disease. I have recently reported subretinal Müller cell membranes in areas of geographic atrophy (GA). These membranes closely mimic areas of retinal pigment epithelial cells (RPE) and choriocapillaris loss. I have also observed Müller cells anterior to drusen expressing glial fibrillary acidic protein (GFAP) and appearing to migrate to the ONL in eyes with AMD. These data indicate Müller cell activation and remodeling in AMD. The stimuli for and consequences of these changes, however, are not understood. We hypothesize that changes to the subretinal milieu in non-neovascular AMD stimulate Müller cell activation and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.