NIH R01 · 2025
Factors Affecting longterm in vitro culture of Treponema pallidum
ABSTRACT Treponema pallidum subsp. pallidum is the causative agents of syphilis, a sexually transmitted infection with an estimated worldwide incidence of 16-32 million new cases per year. The incidence of syphilis in the United States has increased 6-fold over the past two decades. Although this important human pathogen was identified over 100 years ago, the inability to grow T. pallidum in vitro had greatly hampered research into its biology and mechanisms of pathogenesis. In 2018, our group reported continuous long-term multiplication of T. pallidum in co-culture with rabbit epithelial cells and a complex medium. We now have T. pallidum cultures that have been maintained over five years.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.