NIH R01 · 2024
Macrorecombination in isolated cell pairs via natural genetic transformation
Abstract /Summary: Streptococcus pneumoniae (pneumococcus) is a major global bacterial human pathogen, causing ~1 million deaths annually worldwide, due to pneumonia, sepsis, and meningitis. Two strategies are used to combat such infections. Antibiotics can often cure such infections, and vaccines are used to reduce the circulating populations of the most dangerous serotypes. However, both strategies are failing at an increasing rate. Antibiotic resistant strains are continually arising and spreading globally; vaccination effectiveness is also under challenge, as serotypes not targeted by current vaccine formulations are continually arising and rapidly replacing the targeted ones. The cause…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.