NIH R01 · 2024
Edited Magnetic Resonance Spectroscopy of the Pediatric Brain
Summary Human neurochemistry undergoes dramatic changes in early childhood, due to the rapid pace of development. However, techniques for assessing neurochemistry non-invasively by magnetic resonance spectroscopy (MRS) in young children are limited. Spectral editing is the gold-standard for detecting MRS signals from key neurometabolites such as the neurotransmitters glutamate (Glu) and GABA, the neuromodulators N-acetyl aspartyl glutamate (NAAG) and aspartate (Asp), the redox compounds glutathione (GSH) and ascorbate (Asc), the anaerobic glycolysis product lactate (Lac), and the membrane lipid precursor phosphorylethanolamine (PE). Measurement of these lower-concentration metabolites is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.