NIH R01 · 2025
Using germline and somatic genetics to elucidate glioma risk and improve patient outcomes
PROJECT SUMMARY Beginning in 2016 and expanding in 2021, the WHO Classification of Tumors of the Central Nervous System utilizes acquired tumor alterations to classify and grade adult diffuse glioma. Genomewide association studies (GWAS) have identified 30 total germline variants across Europeans and East Asians associated with risk of developing adult diffuse glioma and some with development of specific clinically relevant molecular subtypes. Interestingly, some of these germline variants reside in or near genes that also have acquired tumor alterations in brain tumors. While a GWAS by the three primary 2016 WHO clinical subtypes were conducted, clinical characteristics and outcome…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.