NIH R01 · 2024
Prokaryotic Transcription Termination, Administrative Supplement
PROJECT SUMMARY In the bacterium Escherichia coli, ~40% of transcription termination is factor-dependent termination, mediated by the ATP-dependent RNA translocase Rho, and ~60% of transcription termination is intrinsic termination, mediated by sequences at which transcription yields an RNA hairpin followed by an RNA U-tract. In the archaeon Thermococcus kodakarensis, most transcription termination is factor-dependent termination, mediated by the endoribonuclease and processive exoribonuclease aCPSF1 (archaeal cleavage and polyadenylation specificity factor 1). Bacterial and archaeal transcription initiation and transcription elongation and their regulation are well understood, but…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.