NIH R01 · 2024
Integration of Systems and Synthetic Biology to Advance Development of Human Tissues In Vitro
Project summary/ abstract: Organoids reproduce the complex differentiation, cell sorting and self-organization of organogenesis, enabling the study of tissue development and modeling of organ physiology and disease ex vivo. The induced human Pluripotent stem cell (ihPSC) derived organoids are on their way to revolutionizing the future of human cell/organ transplantations. However, a major challenge is centered around the limited ability to control and direct the dynamic process of self-organization at the cellular population level. This drawback diminishes our engineering efforts to build reliable human tissues by mimicking natural biological processes. As such, currently, human organoids…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.