NIH R01 · 2025
ABSTRACT The complete absence of sperm in the ejaculate is the most severe form of male infertility and termed azoospermia. Azoospermia is remarkably prevalent, affecting 10-20% of infertile men. The majority (~70%) of cases are classified as non-obstructive azoospermia (NOA), an irreversible condition caused by impaired spermatogenesis. NOA is of additional clinical interest due to its association with higher rates of testicular cancer and increased risk of death. Yet, our understanding of NOA is limited, largely because knowledge of the molecules and mechanisms underlying each stage of spermatogenesis is incomplete. Based on my previous research on the transmembrane channel-like (TMC)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.