NIH R01 · 2024
Genetic screens in zebrafish to identify gene-ethanol interactions
Project Summary/Abstract Ethanol is the most common teratogen and the leading cause of mental retardation. Fetal alcohol exposure can cause numerous birth defects, most commonly effecting the nervous system. Fetal Alcohol Spectrum Disorder describes the full range of potential ethanol-induced birth defects and has been estimated to have a prevalence of 10 in 1000 births. The timing and concentration of fetal alcohol exposure are important determinants of FASD phenotypes. There also appears to be genetic susceptibility to FASD, yet we know little about the nature of these susceptibility loci and the mechanisms by which they modify the teratogenicity of ethanol. The zebrafish embryo is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.