NIH R01 · 2024
Quasispecies dynamics in arbovirus persistence emergence and fitness
Arthropod-borne viruses (arboviruses) adapt to local conditions, maximizing their potential to perpetuate and emerge as health threats. The adaptive potential of arboviruses is driven by error-prone replication, which creates a genetically diverse pool of competing virus genotypes within each host. This proposal examines some of the ways that temperature may impact arbovirus evolutionary biology. Our previous research has allowed us to make clear predictions about the outcome of each proposed aim, and generated molecular and computational tools, and methodological approaches that we propose to combine in this project. Global temperatures are changing at an unprecedented rate, and RNA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.