NIH R01 · 2025
Preclinical Electron Paramagnetic Resonance Tumor Imager
Summary Revolutionary methods of acquiring electron paramagnetic resonance (EPR) spectra of free radicals create a paradigm shift in application of EPR to understanding the role of radicals in cancer and in other diseases. Hitherto impossible studies are now feasible. Molecular oxygen, pH, local viscosity, distribution of probes, and general redox status of tissues are crucial parameters to understand tumors, determine targets for radiation and chemotherapy, and to monitor response to treatments. Lung damage, stroke, myocardial infarction, brain injury, wound healing, and other trauma, and peripheral vascular limitations may similarly benefit from EPR imaging of redox status. These…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.