NIH R01 · 2025
Timing of Neuronal Chloride Uptake for Control of Neonatal Seizure
Project Summary and Abstract Neuronal chloride concentration ([Cl-]i) is an important determinant of both post-synaptic GABAA- receptor mediated signaling and cell volume regulation. After injury, neurons swell by admitting water and chloride salts. The chloride moiety alters the reversal potential for GABA signaling, compromising inhibition and contributing to early anticonvulsant-resistant seizures that are thought to worsen long- term outcomes. An important pathway for neuronal entry of water and chloride salts are the reversible cation-Cl- cotransporters (CCC) NKCC1 and KCC2. We hypothesize that emergent limitation of neuronal chloride influx after recovery from hypoxia-ischemia by…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.