Dyment Lab

University of Pennsylvania

ORTHOPEDICS

Philadelphia · United States

NIH-funded
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Research focus

NIH R01 · 2025

Localized small molecule delivery to improve tendon-to-bone integration following anterior cruciate ligament reconstruction

Anterior cruciate ligament (ACL) injuries are one of the leading causes of training and sports related injuries and contribute to post-traumatic osteoarthritis. Torn ACLs are commonly reconstructed, instead of repaired, utilizing a tendon graft that is passed through bone tunnels created in the femur and tibia positioned at the native ACL footprints. Even with advancements in surgical technique and rehabilitation strategies, graft failure and recurrent knee instability are unfortunate complications. Additionally, rehabilitation following surgery is critical to a successful outcome, with premature return to activity resulting in an increased risk of graft failure and reinjury. Consequently,…

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