NIH R01 · 2025
Development of inhibitors to selectively target the CBX8 chromatin reader domain
Project Summary The mis-regulation of chromatin drives both cancer progression and chemotherapy resistance. For example, alterations in the trimethylation of histone 3 at lysine 27 (H3K27me3) is associated with numerous cancers; however, H3K27me3 is also important in numerous normal cellular processes as well. H3K27me3 marks are targeted by the chromodomains of the chromobox (CBX) subunits of Polycomb Repressive Complex 1 (PRC1), which compacts chromatin and represses transcription. There are five CBX paralogs (CBX2,4,6,7,8) that have differential expression in cancer. While CBX6 and CBX7 are often decreased in cancer, CBX2 and CBX8 are frequently increased in cancers. Chromodomains for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.