NIH R01 · 2025
Abscission regulation of corticogenesis
Abstract: In order for the brain to develop with proper size and structure, neural stem cells (NSCs) at early ages must make proliferative divisions and maintain their stemness to expand the stem cell pool, but then switch to undergo neurogenic divisions at the correct time to create neurons. However, the mechanism of this fate choice from remaining an NSC early on, to later choosing to exit the cell cycle and become a neuron, is still poorly understood. The last step of cell division is abscission, which severs the daughter from the mother cell. Abscission occurs during the time when the fate decision is made, and at the apical membrane, where many fate signals are located. We developed…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.