NIH R01 · 2024
Determining drivers of mast cell expansion and function during human airway disease
Project Summary/Abstract: Mast cells (MCs) expand within the airway epithelium and sub-epithelium during prevalent and burdensome human respiratory disease, including asthma and nasal polyposis, where they are thought to play a central role in disease pathobiology. MCs take on discrete protease expression profiles in each location, with sup-epithelial MCs co-expressing tryptase and chymase (MCTC) while epithelial MCs express tryptase alone (MCT). Neither the mechanisms underlying this expansion, the signals directing the epithelial and sub-epithelial MC phenotypes, nor the differential contribution of MC phenotypes to tissue inflammation are well understood. This application focuses on…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.