NIH R01 · 2024
The role of SerpinB2 in insulin resistance and inflammation
Project Summary/ Abstract: Plasminogen activator inhibitor type 1 (PAI-1) and type 2 (PAI-2) are serine protease inhibitors of tissue plasminogen activator and urokinase. PAI-2, which is encoded by SerpinB2, has been shown to be critical to the pathogenesis of different diseases including cancer and nematode infection. However, its role in obesity- associated insulin resistance is not known. Our preliminary experiments revealed that diabetic patients harbored significantly reduced number of SerpinB2+ cells in omental adipose tissue compared to non-diabetic individuals. Moreover, we observed an inverse correlation between the frequency of SerpinB2+ cells and body mass index in patients,…
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