NIH R01 · 2025
Bacterial extracellular vesicles in microbiota-brain communication and hypertension
Project Summary Disruption of the normal gut microbiota composition, termed gut dysbiosis, is an underlying cause of hypertension (HT). The pathway where dysbiosis leads to HT involves gut inflammation, neuroinflammation in the cardiovascular control centers in brain, and ultimately HT. This pathway from gut microbiota to HT requires communications via the microbiota-gut-brain axis (GBA), a multiple component system for the communication between the gut and the brain. Although a number of mechanisms have been described as messengers for GBA communications, our understanding of the GBA in the context of HT is lacking. Extracellular vesicles (EVs) released from bacteria represent a route for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.