NIH R01 · 2025
Targeting the Muscle Metaboreflex to Optimize Exercise Capacity in Stroke Survivors
Stroke survivors are unable to adequately increase and sustain cardiovascular drive during exercise, which limits their capacity to exercise at high intensity. This is clinically meaningful because recent studies indicate that high intensity exercise training (≥70% heart rate reserve, HRR) causes large motor gains post-stroke. However, a central challenge is getting stroke survivors to achieve and sustain sufficiently high heart rates to exercise at high intensity, and sessions can be limited to short bouts of exercise versus a continuous effort. An overlooked mechanism of reduced exercise capacity post-stroke is the dysregulation of sympathetic reflex pathways during exercise. When muscles…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.