Dupont Lab

Research focus

NIH R01 · 2024

Human brain multi-omics to decipher major depression pathophysiology

Major depressive disorder (MDD) is a common disease with high risk of suicide, great social and economic costs, and poor treatment response. Hippocampus neuroplasticity is altered in MDD, susceptible to stress exposure and critical for mood regulation and the establishment of emotional memories in MDD. At the cellular level, our group and others reported fewer granule neurons, fewer astrocytes, and smaller dentate gyrus in MDD. There are conflicting findings about the extent to which new neurons are generated in adult humans, and we showed this happens into the eighth decade of life, while other groups were unable to confirm these findings. Adult neurogenesis is linked to both the…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.